[译] 这个词在拼写上与那个词有很大区别。
[误] This word differs greatly with that one in spelling.

[正] This word differs greatly from that one in spelling.
[注] 表示“与……不同”，应该说 differ from，而 differ with/from 可以表示“与……意见不同或不一致”。We differ from/with him on that question. 我们在那个问题上与他意见不同。