the matter(with)用在带有something, anything, nothing和what等词的句子中，表示“有问题，有毛病”，与wrong (with)意思相似。

• Something is the matter/wrong with my foot.
  我的一只脚出了点毛病。
• Nothing's wrong/the matter with the car — it's just that you're a bad driver.
  汽车并没有问题——只不过你是个拙劣的驾驶员而已。
• What's the matter/wrong with the washing machine?
  洗衣机出了什么毛病？
• I could not understand what was the matter with me.
  我不明白我怎么了。
• Is (there) anything wrong/the matter with her?
  她没什么事儿吧？
• There seems to be something wrong/the matter with her.
  她看起来有点不对劲儿。
• He definitely has something wrong/the matter with his leg.
  他的腿一定有些毛病。